Beads with immobilized amphiphilic molecules, method of fabrication thereof, and method of arraying beads for capillary beads-array

摘要

A capillary beads-array attractive to users is provided by immobilizing amphiphilic molecules on the surface of beads in uniform orientation and arraying the beads in a capillary formed on a soft resin. A monomolecular layer of the amphiphilic molecules is formed on the bead surface by putting beads having hydrophilic portions on the surface in water phase, dropping amphiphilic molecules containing a hydrophilic portion and a hydrophobic portion onto the water phase, pouring an oil lighter than water to form a monomolecular film of the amphiphilic molecules at an oil/water interface, capturing a single bead with the tip of a bead picker, lifting up the tip of the bead picker to allow the bead to reach the oil/water interface, and allowing to form a covalent bond between a functional group in the hydrophilic portion on the bead surface and a functional group in the hydrophilic portion of the amphiphilic molecules.