Method for screening a substance which can suppress degradation of a nuclear receptor or a substance which can promote degradation of a nuclear receptor

摘要

A method is provided for screening a substance which can suppress or promote degradation of a nuclear receptor, comprising the steps of: judging whether or not a test substance can suppress or promote binding of a CHIP with a nuclear receptor via a chaperone protein; and screening a test substance which can suppress the binding as a substance which can suppress degradation of a nuclear receptor or screening a test substance which can promote the binding as a substance which can promote degradation of a nuclear receptor.