METHOD FOR SCREENING A SUBSTANCE WHICH CAN SUPPRESS DEGRADATION OF A NUCLEAR RECEPTOR OR A SUBSTANCE WHICH CAN PROMOTE DEGRADATION OF A NUCLEAR RECEPTOR

摘要

A method is provided for screening a substance which cansuppress or promote degradation of a nuclear receptor, comprisingthe steps of: judging whether or not a test substance cansuppress or promote binding of a CHIP with a nuclear receptor viaa chaperone protein; and screening a test substance which cansuppress the binding as a substance which can suppressdegradation of a nuclear receptor or screening a test substancewhich can promote the binding as a substance which can promotedegradation of a nuclear receptor.