Substituted dihydropyrano indole-3,4-dione derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

摘要

Compounds of formula (I) and II) are provided wherein: X is an alkali metal or a basic amine moiety; R₁ is alkyl, cycloalkyl, —CH₂-cycloalkyl, pyridinyl, —CH₂-pyridinyl, phenyl or benzyl, the rings of these groups being optionally substituted; R₂ is H, halogen, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, —CH₂-cycloalkyl, —NH₂, or —NO₂; R₃ is phenyl, benzyl, benzyloxy, pyridinyl, or —CH₂-pyridinyl, with the rings of these groups being optionally substituted; or a pharmaceutically acceptable salt or ester form thereof, as well as pharmaceutical compositions and methods using these compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis.