Isle gene and its association with osteoarthritis and other bone and cartilage disorders expression products derived therefrom and uses thereof

摘要

The disclosure relates to the ISLR gene, and functional equivalents thereof, such as those from humans and from mice, probes therefor, tests to identify such genes, expression products of such genes, uses for such genes and expression products, e.g., in diagnosis (for instance, risk determination), treatment, prevention, or control of osteoarthritis or rheumatoid arthritis or osteoporosis or other bone disorders or conditions or factors or processes which lead to these disorders or conditions; and to diagnosis, treatment, prevention, or control methods or processes, as well as compositions therefor and methods or processes for making and using such compositions, and receptors therefor and methods or processes for obtaining and using such receptors.