Xenograft model of functional normal and malignant human breast tissues in rodents and methods thereof

摘要

The invention relates to an orthotopic xenograft rodent model in which the stromal and epithelial components of the reconstructed mammary gland are of human origin, and to methods of making the mouse. The invention also relates to methods of using the rodent, including methods of identifying agents or drugs that inhibits abnormal growth of human breast epithelial cells or that inhibit the formation of breast tumors or other hyperplastic growths.