METHOD FOR GENERATING A NON-HUMAN VERTEBRATE ANIMAL MODEL HAVING EITHER TARGET NORMAL TISSUE OF MATURE PHENOTYPE OR TARGET DISEASED TISSUE, A TISSUE MODEL THEREOF AND AN IMMUNODEFICIENT RODENT GENERATED ACCORDING TO SAID METHOD

摘要

The invention relates to the use of fetal tissues to generate a tissue model in a non-human animal. The tissue model comprises target tissues allowed to progress through development in vivo in a non-human host in order to obtain tissues having a mature phenotype that can be sued to assess toxicity and/or efficacy of an agent.