Antitumor agents comprising a targeting portion and an immune response triggering portion

摘要

The present invention provides an antitumor agent comprising a targeting portion and an immune response triggering portion. The targeting portion may be an antibody fragment or a tumor vasculature binding peptide. The immune response triggering portion may be an Fc fragment of immunoglobulin G (IgG), a fragment of the Fc fragment of IgG that exhibits the same biological function as the Fc region, or the extracellular domain of foreign major histocompatability complex (MHC). The antitumor agent is useful for inhibiting tumor growth, inhibiting tumor angiogenesis and treating diseases associated with neovascularization.