HIV-1 envelope glycoproteins having unusual disulfide structure

摘要

The present invention provides HIV-1 envelope glycoproteins having unusual disulfide structure. In particular, the invention includes gp120 polypeptides, and polynucleotides encoding such polypeptides, as well as related vectors, host cells, and expression methods. The invention also encompasses immunogenic compositions containing gp120 polypeptides or polynucleotides and their use in eliciting a gp120-specific immune response. gp120 polypeptides and polynucleotides of the invention are also useful in diagnostic methods of the invention.