GLYT1 conditional knock-out mice

摘要

Vector constructs and methods for producing non-human transgenic animals comprising within their genome a conditional targeted mutation within the glyt1 gene are provided. These animals can be utilized as a tool for assessing GLYT1 function as well as a model for studying the effects of enhancing synaptic NMDA receptor function. In addition, these animals can be utilized for studying the susceptibility to compounds inducing psychotic behavior.