首页>
外国专利>
Screening assays for agonists or antagonists or receptor activator of NF-kappaB
Screening assays for agonists or antagonists or receptor activator of NF-kappaB
展开▼
机译:NF-κB激动剂或拮抗剂或受体激活剂的筛选测定
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides methods for screening for a molecule that antagonizes or agonizes RANK activity. One aspect of the invention involves the growth of RANK responsive cells in semi-solid medium, wherein exposure to a RANK antagonist promotes colony formation. Other aspects of the invention rely on promoter/reporter constructs using RANK responsive promoters derived from the MMP-9 and TRAP genes. Additional aspects of the invention exploit the ability of RANK to activate c-src activity, F-actin ring formation and CaPO4 resorption.
展开▼