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Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
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机译:具有与腺嘌呤和鸟嘌呤结合的修饰碱基的寡聚化合物及其在基因调控中的用途
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摘要
Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers has a modified base for binding to an adenine or guanine base in the opposite strand. Oligonucleotide/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein the oligomer has a modified base for binding to an adenine or guanine base in the opposite strand.
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