首页>
外国专利>
Cell-based therapies for diabetes mellitus and other glucose intolerant states
Cell-based therapies for diabetes mellitus and other glucose intolerant states
展开▼
机译:糖尿病和其他葡萄糖不耐症的细胞疗法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides cells comprising an isolated nucleic acid encoding a novel lactate dehydrogenase (LDH) and/or the encoded LDH polypeptide. The invention further provides cells comprising an isolated nucleic acid encoding LDH, wherein the cell is capable of producing and secreting insulin. Also provided are methods of providing fuel-stimulated (e.g., glucose-stimulated) insulin secreting capability to a mammalian subject by implanting cells of the invention (e.g., in a semi-permeable membrane and/or an implantable device) into the subject. Further provided are devices comprising the cells of the invention. In particular embodiments, the device is an implantable device.
展开▼