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Method for the production of (r)-and (s)-8-chloro-6-hydroxy-octanic acid alkyl esters by enzymatic reduction
Method for the production of (r)-and (s)-8-chloro-6-hydroxy-octanic acid alkyl esters by enzymatic reduction
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机译:通过酶促还原生产(r)-和(s)-8-氯-6-羟基辛酸烷基酯的方法
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摘要
The invention relates to a method for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of the general formula (R)-II or (S)-II in which R has the meaning C1-4-alkyl, from 8-chloro-6-oxooctanoic acid alkyl esters of the general formula I in which R has the above meaning, by enzymatic reduction using alcohol dehydrogenases, such as Lactobacillus brevis or Thermoanaerobium brokii, in the presence of cofactor regeneration systems. The resulting (R)- and (S)-8-chloro-6-hydroxyoctanoic acid esters can be converted in a known manner into (R)-α-lipoic acid and (S)-α-lipoic acid, respectively.
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机译:本发明涉及一种通式(R)-II或(S)-II的(R)-或(S)-8-氯-6-羟基辛酸烷基酯的生产方法 <图像alt =“嵌入式图像” file =“ US20050032180A1-20050210-C00001.GIF” he =“ 39.79mm” id =“ EMI-C00001” imgContent =“ chem” imgFormat =“ GIF” wi =“ 62.31mm” /> Chemistry>其中R具有通式I的8-氯-6-氧辛酸烷基酯的含义C 1-4 Sub>-烷基 <图像alt =“嵌入式图像” file =“ US20050032180A1-20050210-C00002.GIF” he =“ 18.63mm” id =“ EMI-C00002” imgContent =“ chem” imgFormat =“ GIF” wi =“ 59.86mm” /> Chemistry>其中R具有上述含义,是在辅因子再生系统的存在下,通过使用酒精脱氢酶,如短乳杆菌或溴化嗜热杆菌,进行酶还原。可以以已知的方式将所得的(R)-和(S)-8-氯-6-羟基辛酸酯分别转化为(R)-α-硫辛酸和(S)-α-硫辛酸。
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