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Mutations caused by activation-induced cytidine deaminase
Mutations caused by activation-induced cytidine deaminase
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机译:激活诱导的胞苷脱氨酶引起的突变
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摘要
Methods for causing mutations in genes expressed in eukaryotic cells are provided. The methods involve expressing an activation-induced cytidine deaminase (AID) in the cells. The mutated genes can be any gene that is operably linked to a promoter, where the gene is within about 2 kilobases of the promoter. Examples include antibody genes. Also provided are cells expressing AID. The cells can be from any eukaryote, and include hybridoma cells and myeloma fusion partners.
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