Method and apparatus for solid or solution phase reaction under ambient or inert conditions

摘要

The present invention generally provides a novel, automation-compatible solid or solution phase reaction vessel, as well as methods for using such a vessel. Generally, the reaction vessel comprises a microplate assembly with a modular solid phase included within the individual reaction wells. The reaction vessel of the invention allows for the integration of solid phase chemistry with the processing abilities of solution phase chemistry. According to the invention, the microplate assembly and the solid phases are configured so as to integrate together into a single reaction vessel. The combination enables solid phase reactions in a single vessel with full compatibility to liquid handling automation. Further, the combination enables novel methods for performing combination solution phase/solid phase reactions under inert conditions.