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Method for differentiated investigation of diverse structures in preferably biological preparations

机译:在生物制剂中对不同结构进行差异研究的方法

摘要

The invention relates to a method for examining different structures in preferably biological preparations in a differential manner, especially by means of confocal laser scanning microscopy. The method is characterized in that particles having a specific diameter and specific characteristics are assigned to the structures and in that said structures are detected by detecting the particles which have specifically bonded in or to the preparations. The detection process is carried out in an advantageous manner by marking the structures with metal particles with diameters of 10 nm to 1,500 nm and detecting Mie scattering or a plasmon signal.
机译:本发明涉及一种特别是借助于共聚焦激光扫描显微镜以不同的方式检查优选生物制剂中的不同结构的方法。该方法的特征在于,将具有特定直径和特定特性的颗粒分配给结构,并且通过检测在制剂中或制剂中特异性结合的颗粒来检测所述结构。通过用直径为10 nm至1,500 nm的金属颗粒标记结构并检测Mie散射或等离激元信号,以有利的方式进行检测过程。

著录项

  • 公开/公告号US6934022B1

    专利类型

  • 公开/公告日2005-08-23

    原文格式PDF

  • 申请/专利权人 JOHANN ENGELHARDT;

    申请/专利号US20010857960

  • 发明设计人 JOHANN ENGELHARDT;

    申请日1999-12-10

  • 分类号G01N15/02;G01N21/00;G01N21/55;

  • 国家 US

  • 入库时间 2022-08-21 22:21:21

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