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Transcription factor E2F DNA-binding domain inhibitor peptides and their use
Transcription factor E2F DNA-binding domain inhibitor peptides and their use
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机译:转录因子E2F DNA结合域抑制剂肽及其用途
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摘要
The present invention provides peptides which bind to the DNA binding domain of transcription factor E2F, and inhibit cell cycle progression. Peptides include FWLRFT (SEQ ID NO:1); WVRWHF (SEQ ID NO:2); WHFIFW (SEQ ID NO:3); IWLSGLSRGVWVSFP (SEQ ID NO:4); and GSRILTFRSGSWYAS (SEQ ID NO:5) and derivatives based upon these sequences. Compositions and the use of the peptides in inhibiting cell cycle progression, such as in uncontrolled cell proliferation, are also provided.
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机译:本发明提供了与转录因子E2F的DNA结合域结合并抑制细胞周期进程的肽。肽包括FWLRFT(SEQ ID NO:1);和WVRWHF(SEQ ID NO:2); WHFIFW(SEQ ID NO:3); IWLSGLSRGVWVSFP(SEQ ID NO:4); GSRILTFRSGSWYAS(SEQ ID NO:5)和基于这些序列的衍生物。还提供了肽的组成和在抑制细胞周期进程中的用途,例如在不受控制的细胞增殖中的用途。
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