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Novel carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same
Novel carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same
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机译:新型羰基还原酶,编码该羰基还原酶的基因以及使用该羰基还原酶生产旋光性醇的方法
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摘要
According to the present invention, there is provided a novel carbonyl reductase derived from a microbial belonging to the genus Ogataea and a DNA encoding the enzyme. By reducing ketones with the use of the carbonyl reductase, optically active alcohols, in particular, (E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid esters can be produced. The carbonyl reductase according to the present invention is excellent in activity and stereoselectivity. Thus, according to the present invention, there is provided a process for producing optically active alcohols, which are industrially useful as intermediate materials for drugs, pesticides, etc.
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