Lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme

摘要

The present invention provides compounds of Formula (I): chemistry chemdraw filechemistry mol file;or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, R¹, R², U, X, Y, Z, U^a, X^a, Y^a, and Z^a are defined are as defined herein, which are useful as inhibitors of matrix metalloproteinases (MMP), and/or TNF-&agr; converting enzyme (TACE), or a combination thereof.