Bioreactor for cell self-assembly in form of an organ copy; procedures for the production and the application of cell culture, differentiation, maintenance, proliferation and/or use of cells

摘要

The invention concerns a bioreactor in form of an organ copy representing the typical structures of animal or human organs; a procedure to manufacture as well as use the bioreactor for the cultivation, differentiation, maintenance, proliferation and/or use of organ cells or stem cells. The characteristic of this invention is that the specific hollow pathway structures supplying the cells in the open pore body are the exact same configuration as they occur in a natural organ. A further characteristic is the cell culture within open-porous structures, being perfused between the hollow pathway structures, branching out from the center to the periphery and branching in from the periphery to the center. With this bioreactor a device is described that facilitates the reorganization and use of microorganisms or cells in a manner typical to that of the natural organ.