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Fenofibrate-cyclodextrin inclusion complexes and their pharmaceutical composition
Fenofibrate-cyclodextrin inclusion complexes and their pharmaceutical composition
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机译:非诺贝特-环糊精包合物及其药物组成
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摘要
The present invention relates to pharmaceutical compositions containing fenofibrate in the form of an inclusion complex with cyclodextrin, having high dissolution profile and in vivo enhanced bioavailability as compared with plain micronized fenofibrate compositions. An inclusion complex has a molar ratio of fenofibrate (preferably in micronized form) to cyclodextrin of from about 1:0.5 to about 1:4, preferably from about 1:1 to about 1:2. The immediate release fenofibrate composition is preferably in the form of a tablet or in the form of granules inside a capsule.
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