A process for preparing Drug formulations and antichagasicas molecules derived from 2 - nitroimidazoles micro or nano Encapsulated in phospholipid vesicles

摘要

Claim 1: a method for preparing Drug formulations and antichagu00e1sicas molecules derived from 2 - nitroimidazoles as active Principles) in micro or nano vesicles, are characterized by being composed of phospholipids and cholesterol, oligo or multilamellar and possess A size between 100 nm and 2 microns; the amount of active principle, minimum is 0.5 grams / 100 grams lt. claim 2: a method according to claim 1, characterized by antichagu00e1sicas Drugs effective in vivo with widespread Clinical application as active principles derived from 2 - nitroimidazoles: benznidazole and nifurtimox.Claim 3: a method according to claim 1, characterized by the use of Drugs derived from 2 - nitroimidazoles as active Principles misonidazole, etanidazole.Claim 4, a method according to claim 1, characterized by antichagu00e1sicas Drugs effective in vivo without widespread Clinical application as active Principles: ketoconazole, itraconazole, allopurinol, pyrazole - pyrimidines, amphotericin B.Claim 5: a method according to claim 1, characterized by the use of Drugs antichagu00e1sicas effective in Experimental models with predictable Clinical Utility as the active Principles: Peptide inhibitors of cysteine protease of Trypanosoma cruzi (cruzipau00edna, Cruceu00edna); phenothiazines.