Water soluble porphyrin Platinum compounds with high tumor selectivity and its use in preparing medicine for the treatment of benign and malignant tumor Diseases

摘要

Soluble compounds containing porfirin and drugs for the treatment of tumors (benign and malignant). Drugs, including compounds. In particular, these compounds are suitable for photodynamic antitumor therapy. 1. Claim 1: according to formula (1): R is a platinum derivative of formula compound (2) and a platinum derivative of tetrahydrofluorocarbon (a);n = 1-20; X is O, S, NH, N-alkyl; R2 / R3 are H, alkyl, aryl, aralkyl, hetaryl, hetarylalkyl, cycloalkyl; R4 is H, alkyl, aryl, aralkyl, hetaryl, hetarylalkyl, cycloalkyl; R5 is H, alkyl, O-alkyl, S-alkyl, halogen, nitro, cyano, amino, substituted amino; R6 is H, alkyl, O-alkyl, S-alkyl, halogen, nitro, cyano, amino, substituted amino; and according to formula (3);R is a formula compound (4);n = 1-20; X is O, S, NH, N-alkyl; R1 / R2 / R3 / R4 are H, alkyl, aryl, aralkyl, hetaryl, hetarylalkyl, cycloalkyl; or R2-Z-R3, Z is (CH2) n, n = 0-6; R1 / R4 is H, - (CH2) n-COOR8, n = 0-6; R5 is H, alkyl, aryl, aralkyl, hetaryl, hetarylalkyl, cycloalkyl; R6 is H, alkyl, O-alkyl, S-alkyl, halogen, nitro, cyano, amino, substituted amino; R7 is H, alkyl, O-alkyl, S-alkyl, halogen, nitro, cyano, amino, substituted amino; R8 is H, alkyl; and (b) platinum-type derivatives with hematoporphyrin according to formula (5);R2 / R3 is h, asphalt, arilo, aralquilo, hetario, hetarilalquilo, ciclalquilo, R4 is h, asphalt, cyclopropylus, R5 is h, asphalt, cyclopropylus, R6 is h, asphalt, arilo, aralquilo, hetario, hetarilalquilo, cyclopropylus; formula is (6);R1 / R2 / R3 / R4 are H, alkyl, aryl, aralkyl, hetaryl, hetarylalkyl, cycloalkyl or R2-Z-R4, with Z being (CH2) n, n = 0-6; or R1 / R3 is H, - (CH2) n-COOR6, n = 0-6; R4 / R5 are H, alkyl, aryl, aralkyl, hetaryl, hetarylalkyl, cycloalkyl; R6 are H, alkyl, aryl, aralkyl, hetaryl, hetarylalkyl, cycloalkyl; R7 are H, alkyl, aryl, aralkyl, hetaryl, hetarylalkyl, cycloalkyl.