Derivatives of 4 - aryl - 2 (1H) quinazolinona and 4 - 2 - aryl - substituted quinazoline, a process for their preparation, Pharmaceutical compositions and the use of these derivatives for the preparation of a medicament

摘要

The use of derivatives of 4-aril-2 (1H) - quinazolinona and 4-aril-quinazolina 2-alternative formula (1), wherein the remaining formula (2) is selected from the formula residue (3) or (4) of the original or the S; R1 represents the substitutes 1 to 3 independently selected from Oh, SH, halogen, NO2 (low tar, low oxygen), Low calcium, low calcium, low asphalt, low asphalt, low cathode, low cathode, low sulfur, low sulfur, low sulfur, or alternative; R2 is h or (low asphalt, arilo, arilalquilo, cyclopentadiene, cyclopentadienyl)Alternative alternatives: R3 represents one to three alternatives selected from the alternative halogen (low tar, low oxygen or ammonia); R4 'is cyanogen, halogen, nitrogen (- n = n = n),Alternative o (low tar, low oxygen, low thioxyl, ariloxilo, arilalcoxilo or amino), or an acceptable and separable ester or an acid salt for the preparation of drugs to promote the release of thyroid hormones, 1. Pharmaceutical ingredients containing these substances, using these derivatives to prepare drugs to promote the release of thyroid hormones, such as preventing or treating bone conditions related to the increasing depletion or dissolution of calcium;Or where bone formation and calcium fixation need to be stimulated. The preparation process of 4-aril-quinazolinonas derivatives was also introduced.