A method for Industrial Synthesis of Strontium Ranelate and their carbohydrate

摘要

1. Claim 1: procedure for industrial synthesis of strontium formula frog (1),And its hydrate, which is characterized in the formula compound (2),Where R represents a tar (C1-6) group of linear or separated daughters, which reacts with the formula Malon nitrobenzene (3),In methanol, when there is morphine, the content of formula compound per mole is more than 0.95 mol (2),For the abandoned formula compound (4),Where R, as previously defined, then reacts with sulfur in an amount exceeding 0.95 ml per mole of the compound formula (2);The mixture reaction is then heated to reflux; the resulting compound is separated by precipitation before the water surface, and then released by exudation a formula compound (5), wherein R is previously defined and reacts with a formula compound (6).Where R 'represents a linear or separable group of asphalt (C1-6), a recipe of C8-10 tetrabromodiphenyl ether compound, and a group of asphalt in the presence of potassium carbonate in the reflux of organic solvent; then, the reaction mixture is filtered; then, the mixture is concentrated by distillation; The insoluble solvent is then added, the reaction mixture is cooled and filtered to produce a formula compound (7) after drying the resulting powder,In R and RAs mentioned before, the compound formula (7) which reacts with strontium hydroxide is 2 moles or more per mole,During the reflux period of at least five hours, the precipitate generated during heating shall be filtered; the cake generated shall be washed with boiling water, and then the resulting powder shall be dried, and the formula compound (1) and its hydrate shall be discharged. C8-10 tetrabromoammonium compound is a mixture of compound or formula compound: r1r2r3r4n + X -.R1 represents a set of bitumen (C1-6),Each different or identical de2, R3, and R4 represents a rental group (C8-10),X represents a halogen atom