Piridoindolona substituted Derivatives of 3 - a Heterocyclic Group in their Preparation and therapeutic Application

摘要

This refers to piridoindolona derivatives substituted at - 3 by a Heterocyclic Group of General formula (1): in which: - R1 represents a hydrogen Atom or an alkyl group (c1-4); R2 represents a hydrogen Atom or an alkyl group (c1-4); R3 represents a tienilo Monkey Polisubstituido or by a Methyl group or a Heterocyclic radical,;Monocyclic or bicyclic chosen from: a piridilo, N - oxidopiridilo, pyrazole, An (N - phenyl pyrazole (N -), a halogenofenil) pyrazole, a furilo, a indolilo, An (N - benzyl) indolilo, An (N - halogenobencil) indolilo, a benzotienilo, a benzofurilo,And these Radicals are replaced or not replaced one or more times by a Halogen Atom, or a Methyl or methoxy Group; R4 and R5 are identical or different, and each independently represents a hydrogen Atom or a hydroxyl group or Halogen, a hydroxymethyl alkyl (c1-4) , trifluoromethyl, alkoxy (c1-4), alcoxicarbonilo (c1-4)A cyano; procedure of Preparation and Pharmaceutical compositions and their use in the treatment and Prevention of diseases caused or exacerbated by tumor cells.