Heteroaryl compounds which inhibit leukocyte adhesion mediated by Integrin alpha 4

摘要

Described are compounds that bind to Integrin alpha4 Integrin alpha 4, where is preferably vla-4. Some of these compounds can also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by Integrin alpha4 Integrin alpha 4, where is preferably vla-4.These compounds are useful in the treatment of inflammatory diseases in a Mammalian patient, e.g., Human, such as Asthma, Alzheimer's disease, atherosclerosis, Dementia caused by AIDS, diabetes, inflammatory bowel disease, rheumatoid arthritis, transplant Tissues, tumor metastasis and Myocardial Ischemia.The compounds can also be administered for the treatment of inflammatory Brain diseases such as multiple sclerosis.Claim 1: a compound of formula (1), in which each X is independently, Fluorine, Chlorine or Bromine, p is an integer of 0 OR 1 - 3; r1 is selected from the group consisting of methyl and Ethyl; R2 is selected from the Group comprising Lower alkyl, alquenilo Lower, and alquilencicloalquilo Bottom; and their salts are acceptable for pharmaceutical use.