Conjugates of diacid (4S, 8S) - and (4R, 8R) - 4 - methyl - nitrobencil P - 8 - - - - triaza 3,6,9, 3n, 6n, 9N - tricarboximetil undecanoic enantiomerically Pure - 1.11 - with biomolecules, Process for their Preparation and use for preparing Pharmaceutical agents

摘要

(enantiomu00e9ricamente Cigars of a remaining Group of formula (1), where z is a hydrogen Atom or an equivalent of metallic ion of an element of Atomic Number 21 - 29, 31, 32, 37, 39, 42, 44, 46, 47, 49, 58, 71, 75, 77, 82 or 83, is a Group - Coo -, R is a biomolecule and TR Avu00e9s One Functional Group, or alkyl radical C1 - 25 is a linear or branched.Saturated or unsaturated and optionally interrupted by one to six Atoms or phenylene Groups - nhco - with -, -, or a group of formula (2) and / or - NH - (c = o) - NH -, which is optionally substituted anywhere with one to six carboxyl groups hydroxyl groups, amino groups, or other Group. Pos through Functional biomolecules which can be United.And its Salts with inorganic or organic bases, with the condition that the alkyl radical contains at least a biomolecule coupled through a functional Group, and at least two z are equivalent to a Metal Ion. Procedures for the preparation of these conjutados and its use in preparing Pharmaceutical Agents for diagnostic radiology, radiotherapy or Imaging.