ADENOSINE AND ADENOSINE ANALOGUES FOR PRODUCING MEDICINES FOR THE TREATMENT OF THE INSULIN RESISTANCE SYNDROME AND DIABETES

摘要

The invention relates to the use of adenosine compounds described by formula and certain derivatives thereof for producing a medicine for the treatment of the insulin resistance syndrome and diabetes. In the formula, K is N, NO or CH; Q is CH2 or O; R6 is hydrogen, alkyl, allyl, 2-methallyl, 2-butenyl, or cycloalkyl; X is or E is O or S; Y is e.g. hydrogen, alkyl, aralkyl, aryl; n and p are independently 0, 1, 2 or 3, provided that n+p is at least 1; T is e.g. hydrogen, alkyl, acyl, thioacyl, halo, carboxyl; R1R2NCO-, R1R2NCS- or R3OC2H; R1, R2 and R3 are independently H, alkyl, or cycloalkyl; A is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or OR'; B is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or OR"; R' and R" are e.g. independently hydrogen, alkyl, aralkyl or carbomoyl.