Process for preparing a pharmaceutical composition in the form of microspheres with prolonged release of an active princu00ecpio water-soluble, and microspheres

摘要

"Process for the preparation of a pharmaceutical composition in the form of microspheres with prolonged release of an active princu00ecpio water-soluble, and microspheres.The present invention relates to a process for the preparation of a pharmaceutical composition in the form of microspheres with prolonged release of an active ingredient a water-soluble.Characterized by the fact that he understands the succession of the following steps: dissolution of the active principle in a suitable amount of water.Emulsification of the aqueous solution of the active principle thus obtained with a solution of a copolymer matrix D, 1 - lactu00eddeo - Co glicolu00eddeo, of an average molecular weight of between 40000 and 80.000 and having a ratio of lactic acid / glycolic acid ranging from 50 / 50 and 80 / 20, dissolved in a chlorinated hydrocarbon, leading to a first emulsion microfina and homogeneous.Emulsification of that first emulsion thus obtained in an external aqueous phase, containing a surfactant, an agent increases the viscosity and osmotic agent.Evaporation of the solvent extraction to obtain microspheres that recovers after filtration, washing and drying.The invention is also object microspheres, which can be obtained by the implementation of this process.Presenting a continuous release of an active principle over a period of more than two months, with advantage for a period of at least three months.