Methods of treating or preventing Alzheimer's disease and a disease, treating an individual who has, or preventing an individual from contracting, a disease or condition, inhibiting beta-secretase activity, cleavage of a protein precursor isotype amyloid and the production of amyloid beta peptide and beta-amyloid plaque in an animal and producing a beta-secretase complex, use of a compound and composition

摘要

"METHODS TO TREAT OR PREVENT ALZHEIMER AND DISEASE, TREAT AN INDIVIDUAL HAVING, OR PREVENT AN INDIVIDUAL AGAINST, A DISEASE OR CONDITION, INHIBITING THE BETA SECRETASE CLIVING ACTIVITY BETA AND THE PRODUCTION OF PETAID BETA AMYLOID AND BETA AMYLOID PLATE IN AN ANIMAL AND TO PRODUCE A BETA SECRETASE COMPLEX, USE OF A COMPOUND AND COMPOSITION ". The present invention is a method of treating Alzheimer's disease and other diseases and / or inhibiting the beta-secretase enzyme, and / or inhibiting the deposition of beta A peptide in a mammal by the use of known compounds of formula (I) wherein A, R, J and n are as defined herein.