Prevention and treatment of androgen deprivation-induced osteoporosis

摘要

"OSTEOPOROSIS PREVENTION AND TREATMENT INDUCED BY ANDROGEN PRIVACY". The present invention relates to: 1) a method for treating androgen deprivation-induced osteoporosis and / or bone fractures and / or loss of bone mineral density (BMD) in a male subject suffering from prostate cancer. ; 2) a method for the prevention of androgen deprivation-induced osteoporosis and / or bone fractures and / or loss of bone mineral density (BMD) in a male subject suffering from prostate cancer; 3) a method for suppressing or inhibiting osteoporosis induced by androgen deprivation and / or bone abundance and / or loss of BMD in a male subject suffering from prostate cancer; and 4) a method for reducing the risk of developing androgen deprivation-induced osteoporosis and / or bone fractures and / or loss of BMD in a male prostate cancer patient by administering a composition to the individual. A pharmaceutical composition comprising an anti-estrogen agent and / or the analog, derivative, isomer, metabolite, pharmaceutically acceptable salt thereof, pharmaceutical, hydrate, N-oxide thereof, or any combination thereof as described herein.