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E-2-Methoxy-n- (3- (4- (3-methyl-pyridin-3-yloxy) -phenylamino) quinazolin-6-yl) -allyl) -acetamide salt forms, their preparations and their use same against cancer
E-2-Methoxy-n- (3- (4- (3-methyl-pyridin-3-yloxy) -phenylamino) quinazolin-6-yl) -allyl) -acetamide salt forms, their preparations and their use same against cancer
"E-2-Methoxy-N- (3- (4- (3-Methylpyridin-3-yloxy) -phenylamino) -CHI NAZOLIN-6-yl) -Ylyl) -acetamide salt forms, their preparations and their use EVEN AGAINST CANCER ". The invention relates to E-2-Methoxy-N- (3- {4- [3-methyl-4- (6-methyl-pyridin-3-yloxy) -phenylamino] -quinazin-6-malonate succinate and malonate salts) -yl} allyl) -acetamide having the following formula I: Formula 1 More particularly the present invention relates to sesquisucinate and dimalonate salts of formula I. The invention also relates to pharmaceutical compositions containing the succinate and malonate salts of formula I. The invention further relates to methods for treating hyperproliferative diseases, such as cancers, in mammals, especially humans, by administering the above salts and to methods for preparing the above salts.
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