Treatment of pain, inflammation and inflammation-related disorders with a combination of a selective cyclooxygenase-2 inhibitor and aspirin

摘要

"TREATMENT OF PAIN, INFLAMMATION, AND DISORDERS RELATED TO INFLAMMATION WITH A COMBINATION OF A SELECTIVE CYCLOOXYGENASE-2 AND ASPIRIN INHIBITOR". The present invention relates to a method for preventing, treating or ameliorating inflammation-associated pain, inflammation or disorder in a patient in need of such prevention, treatment or amelioration, which involves administering to the patient a selective cyclooxygenase-2 inhibitor. or prodrug thereof and enteric coated aspirin. One method may also involve the administration of a selective cyclooxygenase-2 inhibitor and aspirin in an amount below 75 mg / day. One method may also involve administering a selective cyclooxygenase-2 and aspirin inhibitor, wherein the selective cyclooxygenase-2 inhibitor is BMS-347070, S-33516, CS-502, darbufelone, LAS 34475, LAS 34556, L745337, SD-8381, RWJ-63556, L-784512, COX-189, ABT-963 or valdecoxib or any pharmaceutical or prodrug salt thereof. Also described are compositions, pharmaceutical compositions and kits which may be used with the methods.