TREATMENT OF PAIN, INFLAMMATION, AND INFLAMMATION-RELATED DISORDERS WITH A COMBINATION OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND ASPIRIN

摘要

A pharmaceutical composition comprises one or more discrete orally deliverable dosage forms, each comprising a poorly soluble coxib component in an amount effective when administered once daily for treatment or prevention of a COX-2 mediated disorder, an aspirin component in a cardioprotective effective amount when administered once daily, and at least one pharmaceutically acceptable excipient; the dosage forms having no substantial barrier to intimate commingling of the coxib and aspirin components. A method of simultaneously treating or preventing a COX-2 mediated disorder and providing cardioprotection comprises orally administering such a pharmaceutical composition to a subject in need thereof.