Pharmaceutically acceptable compound or salt or in vivo hydrolyzable ester or amide thereof, process for preparing it, pharmaceutical composition, use of the compound, and methods for producing a hdac inhibitory effect on a warm-blooded animal, and for treating cancer in a warm blooded animal

摘要

"COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT OR HYDROLYZABLE ESTER OR AMID IN VIVO OF THIS PROCESS TO PREPARE PHARMACEUTICAL COMPOSITION, USE OF THE COMPOUND, AND METHODS TO PRODUCE AN INHIBIT EFFECT ON SINGLE ANIMAL, AND A HOT BLOOD ANIMAL ". The invention relates to a compound of formula (I) wherein ring A is heterocyclyl; m is 0 to 4 and each R 4 is a group such as hydroxy, halo, trifluoromethyl and cyano; Ring B is the ring such as thienyl, thiadiazolyl, thiazolyl, pyrimidyl, pyrazinyl, pyridazinyl and pyridyl; R2 is halo and n is 0 to 2 and each R2 is a group such as hydroxy, halo, trifluoromethyl and cyano; p is 0 to 4 and R3 is amino or hydroxy or pharmaceutically acceptable salts or in vivo hydrolysable ester or amide thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of histone deacetylase-mediated diseases or medical conditions.