Methods for preventing, inhibiting, treating or reducing nonalcoholic hepatic steatosis in an animal and for preventing the development and / or reversal of the nafld process in an animal

摘要

"METHODS TO PREVENT, INHIBIT, TREAT OR REDUCE NON-ALCOHOLIC HEPATIC STETHOSIS IN AN ANIMAL AND TO PREVENT THE DEVELOPMENT AND / OR REVERSION OF THE NAFLD PROCESS". The present invention relates to the use of various forms of GIP receptor antagonists to attenuate the insulin response to GIP after meals in animals, such as humans, to prevent, reduce, inhibit and / or treat nonalcoholic liver steatosis. due to its prevention and / or reversal of hyperinsulinemia and insulin resistance. Thus, the use of GIP receptor antagonists in any effective form is believed to prevent the development and reversal of the NAFLD process. The present invention is performed by administering an effective amount of an antagonistic agent, such as a GIP antagonist or antisense molecule, to antagonize, block, inhibit or withdraw the receptor for Glucose Dependent Insulinotropic Polypeptide (GIP).