Compounds and their processes for the preparation, use and pharmaceutical formulations and methods for preventing and / or treating mglur5 receptor mediated disorders and inhibiting mglu r5 receptor activation.

摘要

"COMPOUNDS AND THEIR PROCESS FOR PREPARATION, USE AND PHARMACEUTICAL FORMULATIONS AND METHODS FOR PREVENTION AND / OR TREATMENT OF MGLUR5 RECEIVER MEDIA AND INHIBITION OF MGLUR5 RECEIVER ACTIVATION". The present invention relates to novel compounds of formula (I), a process for their preparation and new intermediates prepared therein, to pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invention which are potent and selective for mGluR Group I receptor and more particularly for mGluR5. Thus, the compounds of the invention are expected to be well suited for the prevention and / or treatment of mGluR5 receptor mediated disorders, such as acute and chronic neurological and psychiatric disorders and acute painful disorders.