Compositions, protein, polynucleotide, method of generating immune response in mammals, detection method, pharmaceutical composition, antibody, non-human transgenic animal, hybridoma, method of delivery of cytotoxic agent or diagnostic agent, and method of inhibiting cancer cell growth.

摘要

"Compositions, protein, polynucleotide, GENERATION METHOD an immune mammalian RESPONSE, THE DETECTION METHOD, PHARMACEUTICAL COMPOSITION, antibody, transgenic animal NOT HUMAN, HYBRIDOMA, AGENT DELIVERY METHOD cytotoxic OR DIAGNOSIS AGENT AND inhibition GROWTH METHOD CANCER CELLS ". The novel gene 098P4B6 (also called STEAP-2), its encoded protein, and variants thereof are described, wherein 98P4B6 exhibits tissue-specific expression in normal adult tissue and is aberrantly expressed in the cancers listed in Table I. Therefore, 98P4B6 provides diagnostic, prognostic, prophylactic and / or therapeutic target for cancer. The 98P4B6 gene or fragment or coded protein or variants or fragment thereof may be used to permit humoral or cellular immunological reaction; 98P4B6 reactive T cells or antibodies can be used for active or passive immunization.