compositions, protein, polynucleotide, method of generating an immune response, detection method, pharmaceutical composition, antibody or fragment thereof, transgenic animal, hybridoma, method of providing a cytotoxic agent or diagnostic agent and method of inhibiting cell growth cancerous

摘要

"COMPOSITIONS, PROTEIN, POLYNUCLEOTIDE, METHOD OF GENERATING AN IMMUNE RESPONSE, METHOD OF DETECTION, PHARMACEUTICAL COMPOSITION, ANTIBODY OR FRAGMENT, TRANSGENIC ANIMAL OR AGNIOTIC DEGENOUS CANCER CELLS ". Innovative genes 098P4B6 (also called STEAP-2) and their encoded protein, as well as variants thereof, are described, wherein 98P4B6 exhibits tissue-specific expression in normal adult tissue and is aberrantly expressed in the cancers listed in Table I. Therefore, 98P4B6 provides diagnostic, prognostic, prophylactic and / or therapeutic target for cancer. The 98P4B6 gene or fragment or coded protein or variants or fragment thereof may be used to provide cellular or humoral immune reaction; 98P4B6 reactive T cells or antibodies can be used for active or passive immunization.