Process for producing a mamu00ecfero become resistant to infection by a herpes vu00ecrus alpha, as well as a mamu00ecfero obtained by application of this procedure and descendant of that mamu00ecfero

摘要

"Process to produce a mamu00ecfero become resistant to infection by a herpes vu00ecrus alpha, as well as a mamu00ecfero obtained by application of this procedure and descendant of that mamu00ecfero".The present invention relates to a process for producing a mammal belonging to a species not human made resistant by transgu00eanese germinal an infection by an alpha herpes virus.For which the HveC polypeptide or nectina - 1 is a functional receptor.The introduction by insertion or homologous recombination into the genome of cells that constitute the mammalian germ lineage, a transgene that allows the expression of a chimeric protein consisting of,On the one hand, the extracellular domain of the nectina - 1 or HveC or one of its parts and, on the other hand, the fragment of an immunoglobulin products, in a suitable expression system.