Compositions and processes for the modification of toxic effects of proteinaceous compounds

摘要

"COMPOSITIONS AND PROCESSES FOR MODIFYING THE TOXIC EFFECTS OF PROTEIN COMPOUNDS". The present invention relates to processes for producing immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leakage syndrome (VLS). The invention further relates to ITs and cytokines that have been mutated to lack VLS-inducing amino acid sequences.