Mutant herpesvu00ecrus 5 cattle, method to prepare a vaccine, vaccine, method to distinguish a ruminant infected with a strain of wild type bhv5 or vaccinated against bhv5, and test kit

摘要

"Mutant herpesvu00ecrus 5 cattle, method to prepare a vaccine, vaccine, method to distinguish a ruminant infected with a strain of wild type bhv5 or vaccinated against bhv5, and.Test kit ". The invention relates to the field of encephalitis in ruminants.The invention provides a mutant of bovine herpesvirus 5 (bhv5) fitted with a functional deletion in each of at least two genes related to clinical manifestation of neurovirulu00eancia when I.Nfecu00e7u00e3o a host with bhv5. In addition, the invention provides a vaccine comprising this mutant.The invention also provides a method to distinguish a ruminant infected with a strain of wild type bhv5 or vaccinated against bhv5 in a population of ruminants vaccinated with a vaccine accordingWith the invention comprising the test of a ruminant by the presence or absence of an antibody directed against the gene of glycoprotein I (GI) or the gene of glycoprotein E (GE) or both.