attenuated mutant strain of a veterinary species-infecting bacterium, vaccine for immunization of veterinary species against a bacterial infection, method for immunizing a veterinary species against a bacterial infection, use of an attenuated mutant strain and method for serological distinction between vaccinated animals and infected animals by an allele-wild strain

摘要

ATTENUATED MUTANT CEPA OF AN INFECTING BACTERIA OF VETERINARY SPECIES, VACCINE FOR IMMUNIZATION OF VETERINARY SPECIES AGAINST A BACTERIAL INFECTION, METHOD OF IMMUNIZING A VETERINARY SPECIES AGAINST A SUCCESSFUL ANCIENT INFECTION, BACTERIAL INFECTION FOR AN ALLELO-WILD STRUCTURE. The present invention relates to the double and triple attenuated mutant strains of an infectious bacterium of veterinary species such as Salmonella enterica, and / or (a pathogenic) Escherichia coli. The mutants of the invention contain at least a first genetic modification and at least a second genetic modification, said first modification in one or more modified genes, and said second modification in one or more genes involved in the survival or proliferation of the pathogen in the host . The present invention also relates to a live attenuated vaccine based on said mutants for the prevention, among others, of Salmonellosis and / or an infection by an E. coli pathogen in a veterinary species.