Pyridazin-3 (2h) -one derivative, compound, process for the preparation of a compound pharmaceutical composition, use of the compound, method for treating a subject suffering from a pathological condition or disease amenable to inhibition phosphodiesterase 4 and combination product

摘要

"PIRIDAZIN-3 (2H) -ON DERIVATIVE, COMPOUND, PROCESS FOR THE PREPARATION OF A COMPOUND PHARMACEUTICAL COMPOSITION, USE OF THE COMPOUND, METHOD FOR TREATMENT OF A SUBJECT THAT IS SUFFERING FROM A PATHOLOGICAL, HARMFUL, DEENLY PATHOLOGICAL CONDITION PHOSPHODIESTERASE 4 INHIBITION AND COMBINATION PRODUCT ". Pyridazin-3 (2H) -one derivatives having formula (I) are found to exhibit PDE-4: where R¬ 1¬, R¬ 2¬ and R¬ 4¬ are organic radicals, R¬ 3¬ is a cyclic group, and R 5 is a ester or an aryl or heteroaryl group.