Derivative compounds 8b - vonil - 11B - (alpha - substituted alkyl) - (10) - 1,3,5 estra trienes; Pharmaceutical compositions; compounds used for Contraception, intermediaries;For the treatment of carcinomas of ovary and granulosa cell tumors.

摘要

This invention relates to 8beta-vinyl-11beta-(omega-substituted)alkyl-estra-1,3,5(10)-trienes of general formula I with ERbeta-antagonistic activity, process for their production, their intermediate products, pharmaceutical preparations that contain the compounds according to the invention, as well as their use for the production of pharmaceutical agents. The new compounds can be used for contraception in men and women without influencing other estrogen-sensitive organs such as the uterus or the liver. They are also suitable for treating benign or malignant proliferative diseases of the ovary, such as ovarian cancer and granulosa cell tumors.