1 - amino - alquilciclohexanos unsaturated as antagonists of NMDA Receptors, 5HT and neuronal nicotinic

摘要

1.- a compound selected from compounds of formula I: where: - * - (R) - N - (cr1r2) nr3r4 m, - n + m = 0, 1, or 2 - is selected from the group consisting of Lower linear or branched alkyl (C1 - C6), alquenilo Lower linear or branched (C2 - C6), and Lower alquinilo linear or ramif Delicate (C2 - C6)- R1 and R2 are independently selected from the group consisting of hydrogen, Lower alkyl linear or branched (C1 - C6), alquenilo Lower linear or branched (C2 - C6), and linear or branched Lower alquinilo (C2 - C6), R3 and R4 are selected independently between q Group EU is Hydrogen, Lower alkyl linear or branched (C1 - C6)Alquenilo Lower linear or branched (C2 - C6), and linear or branched Lower alquinilo (C2 - C6), or together form alquileno (C2 C10) or alquenileno (C2 C10) or with the N form a azacicloalcano or azacicloalqueno 3-7 members optionally substituted by alkyl and / or C1 - 6 C2 - 6 alquenilo,R5 independently selected among the group consisting of Lower linear or branched alkyl (C1 - C6), alquenilo Lower linear or branched (C2 - C6), and linear or branched Lower alquinilo (C2 - C6), or R5 combines with the carbon to which it is attached and a carbon adjacent to p To form a double Union, RP RQ, RRAnd RS are selected independently from the group consisting of hydrogen, Lower alkyl linear or branched (C1 - C6), alquenilo Lower linear or branched (C2 - C6), and linear or branched Lower alquinilo (C2 - C6), or MOP, RQ, RR and RS can be combined independently with the C Arbon which are United and a carbon adjacent to form a double Union, or MOP, RQ, RRRS independently and can form a Union or Double u and which are United...