UNSATURATED 1-AMINO-ALKYLCYCLOHEXANE NMDA, 5HT3 AND NEURONAL NICOTINIC RECEPTOR ANTAGONISTS

摘要

Unsaturated 1-amino-alkylcyclohexane compounds which are systemically-activeas NMDA, 5HT3 and nicotinic receptor antagonists, pharmaceutical compositionscomprising the same, method of preparation thereof, and method of treating CNSdisorders which involve disturbances of glutamatergic, serotoninergic, andnicotinic transmission, treating immunomodulatory disorders, and antimalaria,antitrypanosomal, anti-Borna virus, anti-HSV and anti-Hepatitis C virusactivity.