method hissiku00e4yttu00f6u00f6n the space for reform and mechanism building

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• 2. 基于相对位置动态确定连接建立机制的装置和方法 [P] . 中国专利： CN101631110B . 2013.01.02
• 3. method hissiku00e4yttu00f6u00f6n the space for reform and mechanism building [P] . FI20040376A0 . 2004-03-10

  机译： 方法hissik u00e4ytt u00f6 u00f6n改革和建立机制的空间

• 4. CONSTRUCTION METHOD AND STRUCTURE FOR REFORMING SPACE IN HOUSE BUILDING [P] . 日本专利： JP2008133651A . 2008-06-12

  机译： 房屋建筑空间改造的施工方法和结构

• 5. CONSTRUCTION METHOD AND STRUCTURE FOR REFORMING SPACE IN HOUSE BUILDING [P] . 日本专利： JP2008133650A . 2008-06-12

  机译： 房屋建筑空间改造的施工方法和结构

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• 7. From Discrete Space-Time to Minkowski Space: Basic Mechanisms, Methods and Perspectives [O] . Felix Finster 2008
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• 1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 2. Actuation Spaces Synthesis of Lower-Mobility Parallel Mechanisms Based on Screw Theory [J] . Shihua Li ,Yanxia Shan ,Jingjun Yu . 中国机械工程学报 . 2021,第001期
• 3. 空间规划改革背景下分区规划编制方法研究——以武汉市长江新城规划编制为例 [C] . 王卓标 ,林建伟 . 2019年中国城市规划年会 . 2019
• 4. 全球化和市场化进程中大都市的空间结构及其演化——改革开放以来上海城市空间结构演变的研究 [A] . 付磊 . 2008